Nineteen institutionalized patients with frequent seizures (group average two to three per day seizure types-generalized, akinetic/myoclonic), were treated randomly with either placebo or N,N dimethylglycine (DMG) for 28 days. Department of Neuroscience, University of North Dakota School of Medicine, Fargo. Gascon G Patterson B Yearwood K Slotnick H. These results suggest that DMG enhances both humoral and cell-mediated immune responses in humans. The in vitro responses of lymphocytes from patients with diabetes and those with sickle cell disease to phytohemagglutinin, convanavalin A, and pokeweed mitogen were increased almost threefold after addition of DMA. Production of leukocyte inhibitory factor in response to concanavalin A was similar in the two groups, but those taking DMG tablets had a significantly highr mean response of leukocyte inhibition factor to streptokinase-streptodornase (P less than 0.001).
A double-blind study in 20 human volunteers showed a fourfold increase in antibody response to pneumococcal vaccine in those receiving DMG orally as compared with controls (P less than 0.01). Its potential as an immunoadjuvant has also been suggested by a study of an analog of DMG, calcium pangamate.
Tmg vs dmg stamina free#
J Infect Dis 1981 Jan 143(1): 101-5 PMID: 6163829 UI: 81169354ĭimethylglycine (DMG), a tertiary amino acid, has had wide acceptance as a nonfuel nutrient presumably it enhances oxygen utilization by tissue and complexes free radicals. Graber CD Goust JM Glassman AD Kendall R Loadholt CB. Immunomodulating properties of dimethylglycine in humans. This animal research needs to be extended to humans.Įarly fears that DMG might be mutagenic now appear to be unfounded. On the other hand, an early finding that DMG can enhance both humoral and cell-mediated immune responses has been fortified by some subsequent research. Tests on exercising thoroughbred horses found "no beneficial effects on cardiorespiratory function or lactate production." And male track athletes supplemented with DMG exhibited no significant changes in short-term maximal treadmill performance.
Persistent claims that DMG is useful in autism are thus far anecdotal.Ĭlaims that DMG can boost energy and athletic performance have been refuted by human and animal studies. Several studies show that DMG has no anticonvulsant value and is thus of no help in epilepsy or other conditions characterized by seizures. Nor is it indicated as an energy booster or athletic-performance enhancer.īased on claims that DMG is a highly potent "oxygenator" of body/brain tissues, this supplement has been touted as a panacea for years. It is not indicated as an anticonvulsant, in epilepsy or for any condition characterized by seizures. It is too early to say whether DMG might eventually be indicated as an immune enhancer or in the management of autism. DMG that is not metabolized in the liver is transported by the circulatory system to various tissues in the body. DMG itself is formed from trimethylglycine or betaine. The methyl group produced in this reaction returns to the one carbon pool at the level of N10-hydroxymethyl-tetrahydrofolic acid. Dimethylglycine dehydrogenase, a flavoprotein, is the enzyme that catalyzes the oxidative demethylation of DMG to sarcosine. DMG is metabolized in the liver to monomethylglycine or sarcosine which, in turn, is converted to glycine. TMG is involved in the methylation of homocysteine to form methionine.ĭMG is absorbed from the small intestine and from there transported by the portal circulation to the liver. DMG should not be confused with TMG (trimethylglycine or betaine). DMG is also known as N, N-dimethylglycine, (dimethylamino)acetic acid and N-methylsarcosine.ĭMG is a solid, water-soluble substance. DMG is neither a vitamin nor an essential nutrient. None of those claims, however, was ever substantiated. At present, DMG supplements are available that do contain dimethylglycine.ĭMG-containing calcium pangamate was popular with Russian athletes and cosmonauts because it was reputed to enhance oxygenation at the cellular level, reduce fatigue and enhance physical stamina. Some of these products contained, instead of DMG, a substance called diisopropylammonium dichloroacetate. However, several products entered the supplement marketplace called pangamic acid or calcium pangamate, and these did not contain DMG. Calcium pangamate was intended as a delivery form of DMG. Calcium pangamate was originally a mixture of calcium gluconate and DMG.
DMG appeared as a supplement in the 1960s under the names vitamin B15, pangamic acid and calcium pangamate. There has been much confusion surrounding the history of DMG as a nutritional supplement. DMG is produced in cells as an intermediate in the metabolism of choline to glycine. Dimethylglycine or DMG is a non-protein amino acid found naturally in animal and plant cells.
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